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Index > Protein center > ADRB2(Gene name) > Human
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  • ADRB2 (Gene name),
  • Beta-2 adrenergic receptor (Protein name ),  ADRB2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ADRB2(ADRB2R;B2AR);
    Protein name:
    Beta-2 adrenergic receptor;
    Alternative:
    Beta-2 adrenoreceptor(Beta-2 adrenoceptor);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33.
    Function:
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    413
    Sequence:
    50:
    MGQPGNGSAF | LLAPNGSHAP | DHDVTQERDE | VWVVGMGIVM | SLIVLAIVFG | 
    100:
    NVLVITAIAK | FERLQTVTNY | FITSLACADL | VMGLAVVPFG | AAHILMKMWT | 
    150:
    FGNFWCEFWT | SIDVLCVTAS | IETLCVIAVD | RYFAITSPFK | YQSLLTKNKA | 
    200:
    RVIILMVWIV | SGLTSFLPIQ | MHWYRATHQE | AINCYANETC | CDFFTNQAYA | 
    250:
    IASSIVSFYV | PLVIMVFVYS | RVFQEAKRQL | QKIDKSEGRF | HVQNLSQVEQ | 
    300:
    DGRTGHGLRR | SSKFCLKEHK | ALKTLGIIMG | TFTLCWLPFF | IVNIVHVIQD | 
    350:
    NLIRKEVYIL | LNWIGYVNSG | FNPLIYCRSP | DFRIAFQELL | CLRRSSLKAY | 
    400:
    GNGYSSNGNT | GEQSGYHVEQ | EKENKLLCED | LPGTEDFVGH | QGTVPSDNID | 
    413:
    SQGRNCSTND | SLL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974r
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    Packing:
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    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974h
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    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974d
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    96T
    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974p
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    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974m
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    ELISA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    E9974b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-2 adrenergic receptor
    Cat.:
    U9974h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Cat.:
    P9974Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Cat.:
    P9974Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-2 adrenergic receptor
    Cat.:
    P9974Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Monoclonal Antibody for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor
    Protein for Human Beta-2 adrenergic receptor

    R&D Technical Data
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    s

    s

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    s
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤9.3%

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤5.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.2%

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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Recovery
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    Recovery was determined by spiking various levels of ADRB2 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    102

    97-105

    Plasma

    101

    96-106

     

     

     

     

    Recovery was determined by spiking various levels of ADRB2 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    93

    89-102

    Plasma

    95

    93-105

     

     

     

     

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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ADRB2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    97-105%

    95-108%

    95-110%

    96-109%

    Saliva(n=3)

    96-106%

    95-105%

    95-107%

    93-107%

    heparin plasma(n=5)

    97-103%

     

    93-108%

    92-108%

    94-110%

     

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ADRB2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    90-98%

    89-96%

    91-95%

    85-101%

    EDTA plasma(n=5)

    92-100%

    91-98%

    89-102%

    93-99%

    heparin plasma(n=5)

    90-101%

     

    93-98%

    88-103%

    91-100%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors."
      Chung F.-Z. , Lentes K.-U. , Gocayne J.D. , Fitzgerald M.G. , Robinson D.A. , Kerlavage A.R. , Fraser C.M. , Venter J.C.
      FEBS Lett.211:200-206(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLN-27
      tissue: Brain.
    2. 2.
      "Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions."
      Kobilka B.K. , Frielle T. , Dohlman H.G. , Bolanowski M.A. , Dixon R.A.F. , Keller P. , Caron M.G. , Lefkowitz R.J.
      J. Biol. Chem.262:7321-7327(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-16 AND GLN-27
    3. 3.
      "Primary structure of the human beta-adrenergic receptor gene."
      Schofield P.R. , Rhee L.M. , Peralta E.G.
      Nucleic Acids Res.15:3636-3636(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-16 AND GLN-27
    4. 4.
      "cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor."
      Kobilka B.K. , Dixon R.A.F. , Frielle T. , Dohlman H.G. , Bolanowski M.A. , Sigal I.S. , Yang-Feng T.L. , Francke U. , Caron M.G. , Lefkowitz R.J.
      Proc. Natl. Acad. Sci. U.S.A.84:46-50(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-16 AND GLN-27
    5. 5.
      "Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization."
      Emorine L.J. , Marullo S. , Delavier-Klutchko C. , Kaveri S.V. , Durieu-Trautmann O. , Strosberg A.D.
      Proc. Natl. Acad. Sci. U.S.A.84:6995-6999(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-27
    6. 6.
      "Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects."
      Reihsaus E. , Innis M. , Macintyre N. , Liggett S.B.
      Am. J. Respir. Cell Mol. Biol.8:334-339(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-16; GLN-27; MET-34 AND ILE-164
    7. 7.
      "Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population."
      Rupert J.L. , Monsalve M.V. , Devine D.V. , Hochachka P.W.
      Ann. Hum. Genet.64:135-143(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-27; LEU-159; PHE-159 AND ARG-375
      tissue: Blood.
    8. 8.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-16 AND GLN-27
      tissue: Heart.
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    10. 10.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLN-27
      tissue: Thyroid.
    11. 11.
      SeattleSNPs variation discovery resource
      Submitted (2005-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-27 AND CYS-220
    12. 12.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-27
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ARG-16 AND GLN-27
      tissue: Fetal brain.
      tissue: Leukocyte.
      tissue: Prostate.
    15. 15.
      "Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation."
      Chung F.-Z. , Wang C.-D. , Potter P.C. , Venter J.C. , Fraser C.M.
      J. Biol. Chem.263:4052-4055(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-79
    16. 16.
      "Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor."
      O'Dowd B.F. , Hnatowich M. , Caron M.G. , Lefkowitz R.J. , Bouvier M.
      J. Biol. Chem.264:7564-7569(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-341;MUTAGENESIS OF CYS-341
    17. 17.
      "Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor."
      Valiquette M. , Parent S. , Loisel T.P. , Bouvier M.
      EMBO J.14:5542-5549(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-141; TYR-350; TYR-354 AND TYR-366;PHOSPHORYLATION AT TYR-141
    18. 18.
      "Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors."
      Gurevich V.V. , Dion S.B. , Onorato J.J. , Ptasienski J. , Kim C.M. , Sterne-Marr R. , Hosey M.M. , Benovic J.L.
      J. Biol. Chem.270:720-731(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1 AND ARRB2
    19. 19.
      "Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1."
      Lin F.-T. , Krueger K.M. , Kendall H.E. , Daaka Y. , Fredericks Z.L. , Pitcher J.A. , Lefkowitz R.J.
      J. Biol. Chem.272:31051-31057(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1
    20. 20.
      "A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor."
      Cao T.T. , Deacon H.W. , Reczek D. , Bretscher A. , von Zastrow M.
      Nature401:286-290(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC9A3R1
    21. 21.
      "Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes."
      Luttrell L.M. , Ferguson S.S.G. , Daaka Y. , Miller W.E. , Maudsley S. , Della Rocca G.J. , Lin F.-T. , Kawakatsu H. , Owada K. , Luttrell D.K. , Caron M.G. , Lefkowitz R.J.
      Science283:655-661(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRC AND ARRB1
    22. 22.
      "The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization."
      Moffett S. , Rousseau G. , Lagace M. , Bouvier M.
      J. Neurochem.76:269-279(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECT OF PALMITOYLATION;PHOSPHORYLATION AT SER-345 AND SER-346;MUTAGENESIS OF 345-SER-SER-346
    23. 23.
      "Modulation of postendocytic sorting of G protein-coupled receptors."
      Whistler J.L. , Enquist J. , Marley A. , Fong J. , Gladher F. , Tsuruda P. , Murray S.R. , Von Zastrow M.
      Science297:615-620(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GPRASP1
    24. 24.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-246;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    25. 25.
      "The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization."
      Berthouze M. , Venkataramanan V. , Li Y. , Shenoy S.K.
      EMBO J.28:1684-1696(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP20 AND USP33;INTERACTION WITH USP20 AND USP33
    26. 26.
      "Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL."
      Xie L. , Xiao K. , Whalen E.J. , Forrester M.T. , Freeman R.S. , Fong G. , Gygi S.P. , Lefkowitz R.J. , Stamler J.S.
      Sci. Signal.2:RA33-RA33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN3 AND VHL;SUBCELLULAR LOCATION;INDUCTION;UBIQUITINATION;HYDROXYLATION AT PRO-382 AND PRO-395;IDENTIFICATION BY MASS SPECTROMETRY
    27. 27.
      "SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane."
      Lauffer B.E. , Melero C. , Temkin P. , Lei C. , Hong W. , Kortemme T. , von Zastrow M.
      J. Cell Biol.190:565-574(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27
    28. 28.
      "SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors."
      Temkin P. , Lauffer B. , Jager S. , Cimermancic P. , Krogan N.J. , von Zastrow M.
      Nat. Cell Biol.13:715-721(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL;TOPOLOGY
    30. 30.
      "High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor."
      Cherezov V. , Rosenbaum D.M. , Hanson M.A. , Rasmussen S.G.F. , Thian F.S. , Kobilka T.S. , Choi H.-J. , Kuhn P. , Weis W.I. , Kobilka B.K. , Stevens R.C.
      Science318:1258-1265(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 1-365 IN COMPLEX WITH CARAZOLOL AND CHOLESTEROL;DISULFIDE BONDS;TOPOLOGY;PALMITOYLATION AT CYS-341
    31. 31.
      "A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor."
      Hanson M.A. , Cherezov V. , Griffith M.T. , Roth C.B. , Jaakola V.P. , Chien E.Y. , Velasquez J. , Kuhn P. , Stevens R.C.
      Structure16:897-905(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-365 IN COMPLEX WITH TIMOLOL AND CHOLESTEROL;DISULFIDE BONDS;TOPOLOGY;PALMITOYLATION AT CYS-341
    32. 32.
      "Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties."
      Green S.A. , Turki J. , Innis M. , Ligget S.B.
      Biochemistry33:9414-9419(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-16 AND GLN-27;CHARACTERIZATION
    33. 33.
      "Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype."
      Turki J. , Pak J. , Green S.A. , Martin R.J. , Liggett S.B.
      J. Clin. Invest.95:1635-1641(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-16;POLYMORPHISM
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